活性炭纳米粒子吸附5Fu抗肿瘤作用研讨.pdfVIP

活性炭纳米粒予吸附5Fu抗肿瘤作用研究 赵君贤4扬钟张英鸽。 (警枣医擘科学随褥物鞲物研究掰；纳米药理毒理熏点实验寰) carbon 摘黑：狮究了浠憔凝蚋米鞍子(activated VoPI域染法测定瓣糍规周瀚的 醛5Fu巍体外辩5Fu撬月巾缓律餍的影响，：袋用流试细溅役缝Pl尊染汰霸Anne．tin 影响；裂用警熬缫_曝络宁絷也法栽察绷隐耀亡；采瑁sl啡翻壬；i22小飘勰察ACNP殴瞵5Fu对癍煎潮嫩存时问豹嚣 结袋糖承ACNP麟艇薷增畿5Fu的体内外抗脖瘸{窜嗣，与5Fu奁用诱垮姻膪犁焖翻亡，将桶缝阕期阻辩嶷S嗣， 埘隧怒增强5Fu妫理攀撵朋的桃粼之一。 美键溺：抵胂籀势姆；缝涨褥性碳；人得瘸缨觏；撬胂鳕撵塌 Anti-CancerEffectofActivatedCarbon Nanoparticles 5FuinVitro Adsobing ZHAO Junxian,YANGZhong，ZHANGYingge of and and and (Institute PharmacologyToxicologyKeyLaboratoryofNanopharmacoiogy ofMed{cM 1 Nanotoxicology,BeijingAcademy Sciences，Beijing00850,P‘R。China)。 To the ofactivatedcarbon Abstract：Objectivestudy pharmacodynamics invivoand the ofAC_NPtoinfluencetheanti—tumoreffects 5Fu VitlO,and rrcclmnism adsorbing explore Of5一FU。MethodsUltraviolet wasusedto the of5FuAC≥噜P： spectrophotometrystudyadsorptionby to 酬慝下wasused theanti-cancereffectofACNP dose-and蛙m棼啼l融t study adso小mg5Fu；the ofAeNPwere cell WaSdetectedPI the measured：羽|le relationship cycle by staining；andapoptosisby AnnexinV-Pl andflowcy【om翻潞LThe黝ti《粼t肾actionofA(：NP 5Fuinvivo di．staining adsorbing wasstudied itseffectOnthe oftumorsin and tumor welI byob㈣ing weight Silo H22 bearingmice，a