2016会议课件PDF王文军-高龄妇女卵子量与质的改变-.pptxVIP

高龄妇女卵子质与量的改变;目录;高龄和卵子质量下降的临床表现;25-30岁 活产率最高的年龄段 ＜25岁 或 ＞30岁，活产率下降;高龄和卵子质量下降的临床表现;在20-24岁，流产率8.9% 过了35岁，流产率显著增加;目录;染色体非整倍体率增加;Franasiak,2014 Santiago Munné,2012;染色体错误发生部位;细胞骨架的再调整： 控制卵子不对称分裂;细胞骨架的再调整：细胞骨架重分布;Brunet S, et al. Hum Reprod Update. 2011. 17(1): 68-75;目录;线粒体功能随年龄增加而衰减;;;The importance of mitochondrial metabolic activity and mitochondrial DNA replication during oocyte maturation in vitro on oocyte quality and subsequent embryo developmental competence;The importance of mitochondrial metabolic activity and mitochondrial DNA replication during oocyte maturation in vitro o