艾普拉唑治疗十二指肠球部溃疡疗效观察.docVIP

精品论文 参考文献 艾普拉唑治疗十二指肠球部溃疡疗效观察 庄云英 胡团敏 　　中国人民解放军第180医院 福建泉州 362000 　　【摘 要】目的：观察新型质子泵抑制剂-艾普拉唑对十二指肠球部溃疡愈合的影响。方法：74例经临床症状及内镜检查明确诊断为十二指肠球部溃疡伴幽门螺杆菌感染的患者，随机分为治疗组38例、对照组36例。治疗组口服艾普拉唑10mg , 2次/d；对照组口服奥美拉唑20mg 2次/d；2次/d，疗程4周；同时所有病例服用阿莫西林1.0，2次/d及克拉霉素0.5，2次/d，服药1周。治疗过程中定期观察症状改善情况、检测基础胃酸分泌，疗程结束时胃镜复查。结果：治疗组在缓解症状、降低胃酸分泌、促进溃疡愈合等方面疗效显著，治愈率均明显高于对照组，经比较差异有显著意义，均plt;0.01。结论：艾普拉唑能迅速持续降低胃酸分泌，有效促进粘膜修复，对十二指肠球部溃疡愈合的治疗作用明显优于奥美拉唑。 　　【关键词】艾普拉唑；十二指肠球部溃疡；愈合 　　【中图分类号】R656.6+2 【文献标识码】B 【文章编号】1764-8999（2015）7-0551-01 　　Effect of Ilaprazole on duodenal bulbar ulcer cure 　　 ZHUANG Yun-ying HU Tuan-min , 　　No.180Hospital of PLA,Fujian Quanzhou 362000,China 　　【Abstract】Aim: To investigate the effect of Ilaprazole on duodenal bulbar ulcer cure.Methosd: 74 cases with duodenal bulbar ulcer and Helicobacter pylori infection by clinical symptoms and endoscopy were randomly divided into two group ; treatment group ( 38 cases) were treated with Ilaprazole 10mg, two times a day; control group ( 36 cases) were treated with Omeprazole 20mg two times a day ; taking courses are four weeks and all cases taked Amoxicillin 1.0 two times a day and Clarithromycin 0.5 two times a day , taking courses are one weeks. Regularly observe the improvement of clinical symptoms in the course of treatment, examine the basic gastric acid secretion and review endoscopy .Results: There were significantly different (plt;0.01) that treatment group compared with the control group in alleviating clinical symptoms, reducing the basis of gastric acid secretion and promoting ulcer heal.Conclusion: Ilaprazole can reduce the secretion of gastric acid rapidly and standing , relieve clinical symptoms effectively and rapidly promote mucosa repair and ulcer heal. 　　【Key Words】Ilaprazole; cure； duodenal bulbar ulcer 　　十二指肠球部溃疡是最常见的消化性溃疡，虽然近些年大量研究表明幽门螺杆菌（Helicobacter pylori, Hp）感染是引起十二指肠球部溃疡的重要病因，然而胃酸和胃蛋白酶对胃肠粘膜的自身消化仍然是形成消化性溃疡的不可忽视的直接原因之一[1]，因此随着对消化性溃疡治疗探讨的不断深入，不少学者仍然关注到抑制胃酸分泌是治疗消化性溃疡的主要措施，作为抑酸效果最理想的药物—质子泵抑制剂（PPI）对治