山莨菪碱和蝙蝠葛碱对牛脑动脉平滑肌细胞产生前列腺素的作用-Acta.PDFVIP

·530 · 147 blood platelet aggregation in rabbits． Acta 3 Shan CW ． Effects of polydatin on platelct PharmacolSin 1988；9 ：338 aggregationofrabbits．ActaPharm Sin 1988；23 5Granstrom E， Kindahl H， Samuelesson B 394 Rad forlhromboxaneB2 AnalLeft 4ShanCW ，LiangQZ．Effectsofprocainamideon 1976；9 ：6ll 中国药理学报 ／IetaPharmacotogicaSinica 1990 Nov； 11(6)：530—533 山莨菪碱和蝙蝠葛碱对牛脑动脉平滑肌细胞产生前列腺素的作用 曾国钱、芮擢诚 (第二军医大学药学院药理教研室，上海 200433，中国) lnhibRory effectsofdauricineand anisodamine over 20 mitt 1 B， increased significantly but onproduction ofprostaglandinsonbovineenrn— 6-keto-PGFl reniained unchanged If the cells I~ralarterialsmoothmasclecells0 wcrc preincubated w ith Dau or Ani20 rain before PAF，LTC． orU rD ． stimulation，theprodution of ZENG Guo—Qian，RUI Yao-Cheng TXB2 and 6-keto-PGFk cspcciallyTXB2 werein— (DepattmenlofPharmacology．CollegeofPharmacy hibited significantly compa~d with that of PAF． SecondM ilitaryM ed[calUniversity，Shahghai200433 LTc|orLTD．~roup，respectively． China) Th e results indiae ted that PAF， LrTC． and LTD4 can enhance TXA2 and PGI2，espceialy ABSTRACT The eff~CtS of dauricine (Dau)． TXA，，biosynthesisinbovineanteriorcerebralarteri． anis~amine(Am)，plateletactivatingfactor(PAF)， al smooth musele ce lls．and that Dau and Ani MukotdeneC· (LTC．)andleukotrieneD． (LTD。) normalized thebalance ofTXA，／PGI， ic thecells OlltheproductionofTXB2and6-keto—PGFl (the changedbyPAF LTcJ orLTD．， andthatboth stablemetabolitesofTXA2 andPGI2，respectively)in drugsmay have significance in the prevention and boyin