加味补阳还五汤治疗特发性膜性肾病临床疗效观察Clinical Observation of Modified Bu Yang Huan Wu Tang in Treating Idiopathic Membranous Nephropathy.pdfVIP

提 要 目的：观察在西医基础治疗上，予加味补阳还五汤为主方随症加减，治疗特发性 膜性肾病的临床疗效，探讨中西医结合治疗本病的优势和可行性，为进一步改良及推 广配方打下基础。 方法：本研究收集特发性膜性肾病患者(经肾活检病理诊断为膜性肾病)符合中医 气虚血瘀型患者60例，并随机分为2组，试验组、对照组各30例。对照组予控制血压、 抗凝、降蛋白尿等西医基础治疗，试验组在西医基础治疗上加用加味补阳还五汤，疗 程为二个月。观察临床症状、体征及实验室检查指标的变化，并对症状及体征进行量 化评分，作出疗效评价。 结果：特发性膜性肾病气虚血瘀型中医量化评分：两组患者中医症状体征积分自 身治疗前后比较均有显著差异 (P0.01) 。治疗后组间比较，具有显著性差异(P0.01)， 试验组明显优于对照组。试验组和对照组在提高特发性膜性肾病缓解率方面无显著性 差异；与对照组相比，试验组降低蛋白尿与升高血清白蛋白及降血脂效果稍好，但统 计学均无显著性差异。 结论：加味补阳还五汤配合西医基础治疗特发性膜性肾病气虚血瘀型，能显著改 善患者身倦乏力、颜面或肢体浮肿、腰痛固定或刺痛等临床表现，从而显示出中西医 结合治疗本病的优势，是否有助于提高特发性膜性肾病缓解率有待大样本的进一步研 究。 关键词 加味补阳还五汤；特发性膜性肾病；气虚血瘀型 Clinical Study on idiopathic membranous nephropathy of blood stasis due to qi deficiency with Jia-wei-bu-yang-huan-wu Powder Speciality: Kidney Disease, Nephropathy Medicine of TCM Auther:Ma Zhongwei Tutor:Prof.Mi Jie Abstract Objective: To investigate the effect of Jia-wei-bu-yang-huan-wu Powder treating idiopathic membranous nephropathy of blood stasis due to qi deficiency on the basis of western medicine treatment. To explore the advantages and feasibility of combining traditional Chinese and western medicine treating idiopathic membranous nephropathy and lay the foundation for further improvement. Methods: 60 patients with idiopathic membranous nephropathy of blood stasis due to qi deficiency were divided into 2 groups at random, each group is 30 cases. The control group were treated with basic medicine, while the experimental treatment group were treated with basic medicine and Jia-wei-bu-yang-huan-wu Powder. The course of treatment is 2 months. We would observe the subjects of laborary examination before and after experiment, recorded the change of patients clinical symptoms, at last observed the