- 1、本文档共23页,可阅读全部内容。
- 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
- 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载。
- 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多
糖尿病ACS患者抗血小板治疗PPT
Altered platelet functions in diabetes Diabetic thrombocytopathy refers to differences in platelet function between diabetic and nondiabetic individuals. Both diabetic and prediabetic conditions are associated with platelet and coagulation derangements. Increased platelet aggregability and adhesiveness in diabetes is due to a series of alterations in platelet functions. Because of the importance of platelet aggregation in thrombus formation, treatment strategies have focused on using antiplatelet agents to prevent recurrent events. Summary The objective was to describe the indices of platelet aggregation and activation in a large cohort of diabetic patients with coronary artery disease (CAD). Recently, a number of observations have indicated that patients with diabetes mellitus (DM) exhibit persistent platelet activation,and low response after antiplatelet therapy, although no randomized data exist.We sought to define the baseline platelet biomarkers,and the patterns of response to aspirin and clopidogrel therapy in DM versus non-diabetic patients. Secondary post-hoc analyses were made of platelet activity biomarkers in the dataset which consisted of patients with documented CAD (n=822), including those with DM (n=257). Patients with DM exhibited higher baseline platelet activity by adenosine diphosphate (ADP)- (p=0.0002), and collagen-induced (p=0.03) aggregometry; Ultegra- (p=0.0001), and PFA-100 (p=0.02) analyzers; and expression of platelet/en-dothelial cell adhesion molecule-1 (PECAM-1) (p=0.01), glycoprotein (GP) IIb/IIIa antigen (p=0.001), and activity (p=0.02), vitronectin receptor (p=0.03), P selectin (p=0.02), and intact epitope of PAR-1 thrombin receptor (p=0.02). Antiplatelet response after clopidogrel in diabetics was impaired when compared with non-diabetics. In conclusion, diabetic patients exhibit high pretreatment platelet activity, and do not respond well to the available antiplatelet regimens when compared with similar patients without DM.The
您可能关注的文档
- 第3章第一讲牛顿第一定律牛顿第三定律PPT.ppt
- 第十届世界肺癌会议(英文)PPT.ppt
- 策划书格式及范文PPT.ppt
- 第二次中国临床血脂控制状况多中心协作研究 武阳丰PPT.ppt
- 简历制作及面试技巧方法PPT.ppt
- 第七章、汽轮机调节系统PPT.ppt
- 简单手诊与实际操作PPT.ppt
- 简约ppt模板PPT.ppt
- 等离子质谱法PPT.ppt
- 简约大气实用PPT模板PPT.ppt
- Ⅱ型跨膜丝氨酸蛋白酶:洞察其在恶性血液疾病中的多面角色与诊疗新契机.docx
- 六西格玛质量管理在K公司的深度应用与实践探索.docx
- 黄樟素衍生物的合成路径解析及对肺癌A549细胞增殖抑制的机制探究.docx
- 半夏白术天麻汤合祛风化痰贴治疗缺血性中风恢复期(风痰瘀阻型)的疗效与机制探究.docx
- 回直肠吻合分流术对慢传输型便秘大鼠治疗作用及机制的深度探究.docx
- HIV-1感染早期对髓样树突状细胞的影响与机制探究.docx
- 白细胞介素18与乙型肝炎病毒宫内感染:关联机制与临床意义探究.docx
- 解析良性婴儿癫痫:临床特征与PRRT2基因突变检测的深度洞察.docx
- 城乡小学教师职业生态剖析:职业压力、社会支持与职业倦怠的关联探究.docx
- 黑龙江地区乳腺密度与乳腺癌易感基因SNP的关联解析及临床应用探索.docx
最近下载
- 国家安全论文2000字范文(精选5篇).docx VIP
- 用电检查员技能培训课件—三相四线计量装置错接线分析及操作.pptx
- 第24课 人民解放战争(课件)-【中职专用】《中国历史》.pptx
- 讲好红色故事传承红色精神红色革命故事学习PPT.pptx VIP
- 心理健康指导师考试题库及答案.doc VIP
- 电子基础培训介绍.pptx VIP
- 离心式压缩机培训PPT.pptx VIP
- 犯罪心理学大学校园故意杀人罪的分析以云南大学学生马加爵杀人案为例.pdf
- SLT 631.1-2025 水利水电工程单元工程施工质量验收标准 第1部分:土石方工程.docx
- 高考历史判断题练习及答案.docx VIP
文档评论(0)