完整泪液膜层的干涉图像.docx

Interferometric imaging of the full thickness of theprecorneal tear film完整泪液膜的干涉图像A method is described for recording interference images from the full thickness of the precorneal tear film(PCTF). Simultaneous images are recorded by two video cameras. One camera responds to broadband spectralillumination and records interference from the superficial lipid layer of the tear film. The other camera usesnarrowband illumination and records interference from both the lipid layer and the full thickness of the PCTF.Thus the full-thickness interference fringes are derived from the difference between, or ratio of, narrowbandbroadband images. This method has the potential for evaluating the role of both tear film flow and evaporationin tear film thinning and breakup. It therefore may be applied to the analysis of dry eye disease. ? 2006 OpticalSociety of AmericaOCIS codes: 170.0110, 170.3880, 170.4470, 260.3160, 310.6860.一种记录完整泪液膜（PCTF）干涉图像的方法。图像同时被2个摄像头记录下来。一个摄像头记录宽带光谱在泪膜脂质层产生的干涉图像。另一个用来记录窄带光谱在脂质层和完整膜的干涉图像。因此，窄带图像和宽带图像组成了完整薄膜的干涉图像。这种方法具有评估泪膜流动性和蒸发（当泪膜稀释和干裂）的潜在能力。他可以应用于分析干眼疾病。简介人类的泪膜有很多功能。 它提供液体环境给表面角膜的上皮细胞而且帮助保护对抗微生物和异物。外部表面PCTF 是主要部份使折射眼睛的表面；表面紧张帮助使这表面光滑，如此改良网膜图像的光学质量。另外地，那PCTF 在眨眼期间有一个润滑功能。这些功能能在干的眼睛情况被打乱，一些是最通常的眼睛见到的混乱在眼睛－照料开业者手边。2干的眼睛疾病能带领到泪滴的早熟停止拍摄在一之后眨眼，带领对表面上皮 3,4 的损害和光学的使 .5 模糊PCTF 被帮助的瘦脂质层复盖到 减少在下面水的层的蒸发。 Wolff6 计划，内部的黏液层被传布在 角膜表面被眨眼行动、但是现在视野 这一层是它有薄膜－范围黏液素 形成 glycocalyx 的分子。Interferometry of the PCTF and pre-(contact)-lens tear film (PLTF) can be used both for the measurement of tear thickness and for imaging. Interference in a thin film is described byPCTF和PLTF的干涉测量法都可以被用来测泪膜干涉图像。干涉法在薄膜中描述为：where m_d,__ ,__ is the order of the fringe, n___ and d arethe refractive index and thickness of the film, __ is the(refracted) angle of the beam in the film, and _ is thevacuum wavelength.10 Reflectance of the tear film is thengiven by脂质层折射率比空气和水层高TDF 等厚干涉TDF 等倾干涉WDF 等波长干涉PLTF的厚度 略小于PCTF的厚度。There are two reasons why it is difficult to record corresponding images of the full thi