辛伐他汀联合氯沙坦对兔动脉粥样硬化相关因子的影响.docVIP

精品论文 参考文献 辛伐他汀联合氯沙坦对兔动脉粥样硬化相关因子的影响 （1天津医科大学第二医院 心脏科 天津心脏病学研究所 天津300211 2 天津市滨海新区大港医院 急诊科 天津 300270 3 天津市胸科医院 心脏科 天津300350 摘 要： 目的 研究氯沙坦、辛伐他汀单独以及联合应用对兔动脉粥样硬化的影响和机制。方法 46只新西兰雄性大白兔适应性喂养1周后随机分为空白对照组、高脂组、氯沙坦组、辛伐他汀组、氯沙坦+辛伐他汀组，观察各组药物干预前后体重、血脂、炎症因子的变化。结果 动脉粥样硬化模型建立后，高脂组及药物干预组血脂水平显著高于空白对照组（Plt;0.05）,高脂组与药物干预组间比较无统计学差异。药物干预8周后，药物干预组IL-6、MCP-1均明显低于高脂组（Plt;0.05），氯沙坦+辛伐他汀组IL-6较氯沙坦组、辛伐他汀组无差异（Pgt;0.05），MCP-1较氯沙坦组有明显下Plt;0.05），氯沙坦与辛伐他汀组组间无差异（Pgt;0.05）。氯沙坦组、辛伐他汀组PPARgamma;无明显差异（Pgt;0.05），氯沙坦+辛伐他汀组PPARgamma;较其他组别明显升高（Plt;0.05）。药物干预组比高脂组内膜中膜厚度比均有显著下降（Plt;0.05），氯沙坦+辛伐他汀组较氯沙坦组、辛伐他汀组明显降低 Plt;0.05）。结论 氯沙坦及辛伐他汀均能显著减少内膜中膜厚度比，稳定血管斑块，联合治疗具有更强的延缓动脉粥硬化进程的作用，独立于降低血脂的抗动脉粥样硬化作用可能与降低炎症因子密切相关。 关键词：氯沙坦 辛伐他汀 白介素-6 单核细胞趋化蛋白-1 过氧化物酶体增殖物激活受体gamma; 【中图分类号】R543.5【文献标识码】A【文章编号】1001-5213(2016)09-0122-02 中图分类号：R543.5 文献标识码：B Synergetic effect of losartan and simvastatin on atherosclerosis related factors in rabbits ZHANG Zong-yan1.2, XU Yan-Min1 , LIU Yuan-ying3 （1.Department of Cardiology ,Tianjin Institute of Cardiology，the Second Hospital of Medical University，Tianjin 300211；2. Emergency department ,Dagan g Hospital of Tianjin Binhai New Area,Tianjin 300270,China；3 Department of Cardiology ,Tianjin Thoracic Hospital, Tianjin 300350, China） ABSTRACT: Objective To investigate the effect and mechanism of simvastatin and losartan synergistically inhibite the atherosclerosis progression in rabbits. Methods 46 New Zealand male rabbits adaptive feeded after 1 week were randomly divided into five groups: normal control group(NC group), high-cholesterol group(AS group), Losartan group(L group), Simvastatin group(S group) and Losartan Simvastatin group(LS group).The level of weights, lipids and inflammatory factors were detected before and eight weeks after the drugs intervention. Results After we builted the AS model, the lipid level of AS group and drug intervention group were higher compared with NC group. There was no significant difference (Pgt; 0.05) between AS group and drug intervention gr