铝碳酸镁联合泮托拉唑治疗应用于活动期胃溃疡的疗效观察.docVIP

精品论文 参考文献 铝碳酸镁联合泮托拉唑治疗应用于活动期胃溃疡的疗效观察 信桂强（临沂市康复医院 山东 临沂276000） 　　摘要：目的：探讨铝碳酸镁联合泮托拉唑治疗应用于活动期胃溃疡的临床疗效。方法：2014 年5 月至2015 年5 月期间，我院84 例活动期胃溃疡患者，根据随机数字法，将其分为对照组（泮托拉唑）和观察组（铝碳酸镁联合泮托拉唑），每组各42 例，比较两组治疗后临床症状评分变化、幽门螺杆菌根除率、临床疗效，以及不良反应。结果：与对照组相比，观察组治疗后上腹痛、腹胀、嗳气、返酸、烧心等临床症状评分均明显降低，Plt;0.05；与对照组相比，观察组幽门螺杆菌根除率、治疗的总有效率均明显提高，Plt;0.05。治疗期间两组都没有出现明显不良反应。结论：铝碳酸镁联合泮托拉唑治疗明显改善活动期胃溃疡患者的临床症状，提高治疗的临床疗效。 　　关键词：铝碳酸镁；泮托拉唑；活动期胃溃疡；疗效【中图分类号】 R2 【文献标号】 A 【文章编号】 2095-7165（2015）13-0008-02The efficacy observation of hydrotalcite combine with pantoprazole applied in the activegastric ulcerAbstract: Objective：To study the clinical efficacy of hydrotalcite combine with pantoprazole applied in the active gastric ulcer. Methods：The 80 patientswith active gastric ulcer in our hospital during the period from May 2014 to May 2015 were randomized into the control group (pantoprazole) and theobservation group (hydrotalcite combine with pantoprazole) according to the random number method, 42 patients per group. The changes of clinical symptomscores on post-treatment, helicobacter pylori eradication rate, clinical efficacy and adverse reactions in the two groups were compared. Results：Compared withthe control group, the clinical symptom scores such as abdominal pain, abdominal distension, belching, acid regurgitation, heartburn were significantly decreasedon post-treatment in the observation group (Plt;0.05); compared with the control group, the helicobacter pylori eradication rate and total effective rate wereobviously increased in the observation group (Plt;0.05). There were no serious adverse reactions in the two groups. Conclusion：The treatment of hydrotalcitecombine with pantoprazole can significantly improve clinical symptoms of active gastric ulcer and increase the clinical efficacy.Key words: Hydrotalcite; pantoprazole; Active gastric ulcer; Efficacy 　　活动期胃溃疡作为临床常见的消化道疾病之一，具有迁延不愈、易癌变等特点，严重影响着患者的生活质量［1］。治疗主要以根除螺旋杆菌、抑制胃酸分泌、保护胃粘膜为主，而铝碳酸镁作为胃粘膜保护剂，不仅能促进胃粘膜及粘液层中修复因子合成，还能有效抑制幽门螺杆菌的定植［2］。 　　1 资料与方法1.1 一般资料2014 年5 月