附子不良反应与煎煮时间、使用剂量的相关性分析.docVIP

精品论文 参考文献 附子不良反应与煎煮时间、使用剂量的相关性分析 （山东省济南市第五人民医院药房，山东 济南 250022） 中图分类号 R282 文献标志码 A 文章编号 1008-0408（2015）2-0032-02 摘 要 目的：分析研究附子不良反应的发生与煎煮时间及使用剂量的相关性。方法：抽取我院2013年6月到2014年9月间收治的寒湿痹阻型痹证患者200例作为研究对象，所有患者均给予相同的中药处方治疗，但一组在处方中加入附子，另一组未加，两组各有100例，分别将其设为观察组和对照组，比较两组患者治疗期间的不良反应发生率。同时，按照患者治疗期间是否发生不良反应对观察组患者进行组内再分组，分别对其煎煮时间、附子使用剂量等进行比较。结果：观察组患者和对照组患者的不良反应发生率分别为52.0%和12.0%，观察组患者均显著高于对照组，差异有统计学意义（P＜0.05）。观察组中，不良反应发生组患者的附子使用剂量显著高于未发生组，但先煎时间和总的煎煮时间均显著低于未发生组，比较均有统计学差异（P＜0.05）。结论：附子是一味具有大毒型的药物，处方中附子的使用剂量、煎煮时间都与其不良反应的发生息息相关。 关键词 附子；不良反应；煎煮时间；使用剂量 Abstract objective: to study the occurrence of adverse reactions and lateral root of aconite decoction time and dosage of relevance. Method: extract from June 2013 to September 2014 and dampness bizu type 200 cases of patients as the research object, all the patients were given the same Chinese medicine prescription treatment, but a group to join in the prescription of aconite, another group without, two groups with 100 cases each, it set as observation group and control group respectively, compared two groups of patients during treatment the incidence of adverse reactions. At the same time, according to patients during treatment whether adverse reactions to within the group to group, observation group of patients, respectively, the decoction time, dosage of lateral comparison. Results: the incidence of adverse reactions of the observation group of patients and the control group patients were 52.0% and 12.0% respectively, the observation group patients were significantly higher than that of control group, the difference was statistically significant (P lt; 0.05). In the observation group, the group of patients with adr of the use of lateral dose group is significantly higher than did not happen, but first the frying time and total time decoction group were significantly lower than not, more were statistically significant (P lt; 0.05). Conclusion: the monkshood is blindly with large poisonous drugs, prescription of dosa