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Mangiferin, an anti-HIV agent targeting protease effective against resistant strains精选.pdf

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Mangiferin, an anti-HIV agent targeting protease effective against resistant strains精选

Molecules 2011, 16, 4264-4277; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Mangiferin, an Anti-HIV-1 Agent Targeting Protease and Effective against Resistant Strains Rui-Rui Wang 1,†, Yue-Dong Gao 2,3,†, Chun-Hui Ma 4, Xing-Jie Zhang 1,3, Cheng-Gang Huang 4,*, Jing-Fei Huang 2,* and Yong-Tang Zheng 1,* 1 Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2 State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3 Graduate School of Chinese Academy of Sciences, Beijing 100039, China 4 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: huangjf@ (J.-F.H.); cghuang@ (C.-G.H.); zhengyt@ (Y.-T.Z.); Tel.: +86 871 5195684; Fax: +86 871 5195684. Received: 25 February 2011; in revised form: 6 May 2011 / Accepted: 13 May 2011 / Published: 24 May 2011 Abstract: The anti-HIV-1 activity of mangiferin was evaluated. Mangiferin can inhibit HIV-1ⅢB induced syncytium formation at non-cytotoxic concentrations, with a 50% effective concentration (EC50) at 16.90 μM and a therapeutic index (TI) above 140. Mangiferin also showed good activities in other laboratory-