Matrix metalloproteinases and genetic mouse models in cancer research a mini-review2747-6精选.pdfVIP

Tumor Biol. DOI 10.1007/s13277-014-2747-6 REVIEW ARTICLE Matrix metalloproteinases and genetic mouse models in cancer research: a mini-review Edyta Wieczorek Ewa Jablonska Wojciech Wasowicz Edyta Reszka Received: 29 July 2014 /Accepted: 15 October 2014 # The Author(s) 2014. This article is published with open access at S Abstract Carcinogenesis is a multistep and also a multifacto- during the process of carcinogenesis. Tumor growth and me- rial process that involves agents like genetic and environmental tastasis formation depend on the cell-cell and cell-matrix factors. Matrix metalloproteinases (MMPs) are major proteo- interactions and also modifications of the tissue through the lytic enzymes which are involved in cancer cell migration, action of proteolytic enzymes [1–3]. In the early 1980s, Liotta invasion, and metastasis. Genetic variations in genes encoding et al. indicated in in vitro studies on mouse cancer cells the the MMPs were shown in human studies to influence cancer importance of these enzymes in the process of metastasis [4]. risk and phenotypic features of a tumor. The complex role of Members of the MMP family of extracellular proteases in- MMPs seems to be important in the mechanism of carcino- clude six subgroups which, due to differences in their structure genesis, but it is not well recognized. Rodent studies concen- domain, may be involved in a large variety of physiological trated particularly on the better understanding of the biological and pathological processes [5]. The large family of MMPs is functions of the MMPs and their impact on the pathological composed of 25 endopeptidases in humans and 24 in mice [6, process, also through the modification of Mmp genes. This 7]. MMP enzymes play a significant role in cancer invasion, review