生物化学原理教学（杨荣武）Chapter28 Metabolism of fats, phospholipids and glycolipids.pptVIP

Outline Fat metabolism Digestion and absorption of lipid Mobilization of fat from the adipose tissues Phospholipid metabolism Glycolipid metabolism (self-study) Fat from Diet Adipose Cells Triacylglycerols either way Triglycerides represent the major energy input in the modern diet (but it wasnt always this way) Triglycerides are also the major form of stored energy in the body Hormones (glucagon, epinephrine, ACTH) trigger the release of fatty acids from adipose tissue Fat synthesis Mobilization of glycerol Formation of phosphatidate TG formation Phospholipid metabolism Hydrolysis of Phospholipid – catalyzed by various phospholipases Phospholipid Synthesis Formation of phosphatidate Activation of head groups or DG (two strategies) Attachment of head groups * 杨荣武生物化学原理第二版 Chapter28 Metabolism of fats, phospholipids and glycolipids from McDonalds to Metabolism… The chylomicron: a lipoprotein Hormone-dependent degradation of Fat to release FFAin adipose tissue Hormone Receptor second messenger kinase cascade Target enzyme Hormone-dependent degradation of Fat in adipose tissue Utilization of glycerol Mobilizing glycerol 1. Formation of phosphatidate 2. TG formation Acyltransferase Acyltransferase Acyltransferase Phosphatase Specificities of Several phospholipases