第五章 肿瘤D.ppt

肿瘤发生的分子基础;*;肿瘤的病因学和发病学;肿瘤发生的分子生物学基础;The chromosomal translocation and associated oncogenes in Burkitt lymphoma and chronic myelogenous leukemia ;Model for action of RAS genes ;The role of RB in regulating the G1-S checkpoint of the cell cycle ;The role of p53 in maintaining the integrity of the genome ;Simplified schema of CD95 receptor-induced and DNA damage-triggered pathways of apoptosis and mechanisms used by tumor cells to evade cell death. (1) Reduced CD95 level. (2) Inactivation of death-induced signaling complex by FLICE protein. (3) Reduced egress of cytochrome c from mitochondrion as a result of up-regulation of BCL2. (4) Reduced levels of pro-apoptotic BAX resulting from loss of p53. (5) Loss of APAF-1. (6) Up-regulation of inhibitors of apoptosis. ;肿瘤发生的分子生物学基础;环境致癌因素;环境致癌因素;CIN Ⅰ;EBV RNA;Proliferation;影响肿瘤发生发展的内在因素;小 结