药用高分子材料sirna药物PPT.pptxVIP

姚老师作业：聚乳酸的本体聚合工艺，相应机理和反应方程;第六章 高分子纳米药物-siRNA药物; 抗体: Bind protein, but only extracellular epitopes Low throughput, high cost 反义RNA/核酶: Stop gene expression (production), most proteins Chemical stabilization essential Barriers: sequence selection, potency, toxicities, … RNA干扰: Stop gene expression (production), most proteins Good activity without chemical stabilization Rapidly replacing antisense: really better? ;RNA干扰（RNA interference, RNAi）技术;RNAi 作用机制;Target ID; Company ;难以被细胞摄取：大分子，阴离子;Nature 2010, 468, p487, Nov. 25, 2010;表达siRNA的质粒DNA的传递 病毒（Nature Biotechnology, 2002, 20: 1006-10） 非病