抗氧化应激转录因子Nrf2的研究进展精选.pdf

· 1234· 中国病理生理杂志 ChineseJournalofPathophysiolo~ 201l，27(6)：1234一1239 [文章编号] 1000—47182【011)06—1234—06 抗氧化应激转录因子 一Nrf2的研究进展冰 林晓萍 ， 李 雯， 沈华浩 (浙江大学医学院附属第二医院呼吸科 ，浙江 杭州310009) Progressonantioxidanttranscription factor—·Nrf2 LIN Xiao—ping，LIWen，SHEN Hua—hao (DepartmentofRespiratoryMedicine，TheSecondAffiliatedHospital，ZhejiangUniversitySchoolofMedicine， Hangzhou310009，China．E—mail：hh _ shen@yahoo．corn．cn) 【ABSTRACT】 Nuclearfactor—E2一relatedfactor2(Nrt2)playsacriticalroleintheregulationofcellularredox status．Undernormalhomeostaticconditions，Nrt2transcriptionisrepressedbyitsnegativeregulatorKelch—likeepichloro- hydfin~associatedprotein1(Keap1)．However，uponexposuretooxidativestress，Nrf2dissociatesfromeytoeslicKeapl andtranslocatestOthenucleus，whereitbindstothecorrespondingresponseelement(ARE)inthepromoterregionofthe genesencodingantioxidantenzymesandphase2detoxifyingenzymestoinducetheexpressionofendogenouscorresponding enzymes．Nrt2一inducedantioxidantprotectioninvolvesincancer，inflammation，respiratorydiseases，cardiovasculardis— eases，neuredegeneration，autoimmunediseasesnadSOon．Onthecontrary，disruptionorinactivationofNrf2willaggra— vatetheeytotoxieityofoxidativestress leadingtothecellulardysfunction，apoptosisorevendeath．Thepurposeof thisre- ． ， ． viewistointroducetheinteractionbetweenNrt2andKeap1，andthelatestresearchprogressonthefunctionofNrt2． [关键词] 核因子 E2相关因子2；Kelch样环氧氯丙烷相关蛋白一1；氧化性应激 [KEYWORDS] Nuclerafactor—E2一relatedfactor2；Kelch—likeECH—associatedprotein1；Oxidativestress [中图分类号] R363． [文献标识码】 A doi：10．3969／j．issn