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Langenbeck’s Arch Surg (2002) 387:240–245 DOI 10.1007/s00423-002-0313-y O R I G I N A L A RT I C L E Masahide Ikeguchi Thymidine phosphorylase Masato Makino Nobuaki Kaibara and dihydropyrimidine dehydrogenase activity in colorectal carcinoma and patients prognosis Received: 15 March 2002 Abstract Background and aims: 5- were not correlated with tumor loca- Accepted: 30 July 2002 Fluorouracil (5-FU) is a widely used tion or histological types of tumors. Published online: 18 September 2002 for colorectal carcinoma. However, Even tumor TP and TP/DPD values © Springer-Verlag 2002 the therapeutic effect of 5-FU differs in Dukes’ stage A tumors were lower among patients. This difference may than those of other stages; DPD val- be based on the difference in sensi- ues were not correlated with tumor tivity of carcinoma cells to 5-FU. stages. In 100 patients who under- The activities of thymidine phospho- went intravenous adjuvant 5-FU che- rylase (TP) and dihydropyrimidine motherapy, prognosis was not corre- dehydrogenase (DPD) are reported lated with tumor-TP, DPD, or to be correlated with cancer cell sen- TP/DPD values. Moreover, in 20 pa- sitivity against 5-FU in vitro. We tients with synchronous liver metas-