microRNA 作用PPT.ppt

Using anti-atherosclerosis microRNA for gene therapy;Atherosclerosis;95年台灣十大死因統計;Drug discovery for atherosclerosis;Screening model for atherosclerosis(1);Screening model for atherosclerosis (2);Searching for new mechanisms for 三七 anti-atherosclerosis effect;microRNA (miR) function;*;In vitro and In vivo study for atherosclerosis;microRNA Array for screening ;miR-2xx miR-1xxb miR-2xx miR-4xx miR-4xx miR-4xx miR-5xx miR-4xx miR-1xx miR-2xx;microRNA-1xx levels after drug treatment;microRNA-1xx anti-atherosclerosis effect (anti-proliferation);microRNA-1xx anti-atherosclerosis effect – anti-migration;Compare microRNA-1xx vs other drug for anti-atherosclerosis;Predict miRNAs target genes;Based on the bioinformatic prediction, CXCLn and Cyclin E1 gene are two of miR-1xx target gene. 2. We transfected with pre-miR-1xx to the VSMC cells can reduce CXCLn and Cyclin E1 expression with a dose dependent manner. ;Biomarker screening for atherosclerosis;Biomarker screening for atherosclerosis;miR-1xx in human serum;miR-1xx in rat carotid artery after balloon injury;microRNAs gene therapy;Thanks for your attention