抗栓领域新进展PPT.pptVIP

Bristol-Myers Squibb/Pfizer A Phase III Study of Apixaban in Patients With AF The purpose of this clinical research study is to learn if apixaban is more effective than Acetylsalicylic Acid (ASA) in preventing strokes associated with subjects who have atrial fibrillation. The safety of this treatment will also be studied. * AVERROES是一项随机双盲试验，旨在房颤患者中比较阿匹沙班和阿司匹林的疗效。入选全球522所医院的5600例房颤患者（平均年龄70岁，具有≥1项卒中危险因素），患者因难以控制治疗效果、出血风险增加、拒绝服用华法林等原因不适合维生素K拮抗剂（VKA）治疗。将患者随机分为阿匹沙班组（5 mg BID，部分患者2.5mg BID）和阿司匹林组（81-324 mg)。主要疗效终点是卒中和系统性栓塞，主要安全性终点是严重出血。次要和三级终点是卒中、系统性栓塞、心肌梗死、血管性死亡和全因死亡。 * A Phase 3, Active (Warf