原创力文档In Silico king and Electrophysiological Characterization of Lacosamide Binding Sites on Collapsin Response Mediator Protein 2 Identifies a Pocket Important in Modulating Sodium Channel Slow Inactivation英文文献.pdfVIP
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Supplemental Material can be found at:
/content/suppl/2010/06/09/M110.128801.DC1.html
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 285, NO. 33, pp. 25296–25307, August 13, 2010
© 2010 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in the U.S.A.
In Silico Docking and Electrophysiological Characterization of
Lacosamide Binding Sites on Collapsin Response Mediator
Protein-2 Identifies a Pocket Important in Modulating
□
Sodium Channel Slow Inactivation* S
Received for publication, April 23, 2010, and in revised form, May 28, 2010 Published, JBC Papers in Press, June 9, 2010, DOI 10.1074/jbc.M110.128801
Yuying Wang‡1 §1 ‡1,2 ¶ § § ‡‡ ‡
, Joel M. Brittain , Brian W. Jarecki , Ki Duk Park , Sarah M. Wilson , Bo Wang ** , Rachel Hale ,
Samy O. Meroueh§**‡‡, Theodore R. Cummins‡§, and Rajesh Khanna‡§3
From the Departments of ‡ ‡‡
Pharmacology and Toxicology, Chemistry, and **Biochemistry and Molecular Biology, the Center for
Computational Biology and Bioinformatics, and §Program in Medical Neuroscience, Paul and Carole Stark Neurosciences Research
Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202 and the ¶Division of Medicinal Chemistry and Natural
Products, Eshelman School of Pharmacy, University of North Carolina, C
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