磁共振3d-ciss序列与3d-space序列颅内脑脊液成像的对照分析word论文.docxVIP

磁共振 3D-CISS 序列与 3D-SPACE 序列对颅内脑脊液成像的对照研究 华中科技大学同济医学院附属协和医院放射科 硕士研究生：梅 豪导师：余建明教授摘 要目的：评估 3D SPACE 序列和 3D CISS 序列在 3T 磁共振上水成像的差异， 为临床磁共振选择合适的三维水成像序列进行颅内脑脊液成像以及身体其他部 位水成像提供参考。方法：选取我院 2013 年 3 月-2014 年 4 月脑脊液检查志愿者和病人 40 例, 其 中中脑导水管梗阻病人 5 例,在 3T 磁共振上分别以 3D-SPACE 序列与 3D-CISS 序列行脑脊液成像检查。分析两个序列在中脑导水管附近和侧脑室内脑脊液的伪 影，运用配对χ2 检验进行统计学处理，比较这两个序列在不同流速的水成像中 伪影差异。测量侧脑室内脑脊液和脑干组织的信号强度并计算脑脊液信号的信噪 比和对比噪声比,通过配对 t 检验比较两个序列在相对静止水成像中脑脊液信噪 比和对比噪声比的差异，并比较不同序列在侧脑室内和中脑导水管附近脑脊液信 号强度的差异，以此分析不同流速的脑脊液对两个序列脑脊液信号强度的影响。结果：1、颅内脑脊液的侧脑室位置，SPACE 序列与 CISS 序列都不产生流空伪影， 而在中脑导水管及附近位置 SPACE 序列容易产生流空伪影，CISS 序列不易产生 流空伪影；2、SPACE 序列侧脑室脑脊液的信噪比和对比噪声比均高于 CISS 序列；3、SPACE 序列脑脊液的信号强度受液体流速影响，而 CISS 序列的脑脊液 信号强度对流速不敏感。I结论：1、在颅内脑脊液成像中，3D CISS 序列优于 3D SPACE 序列。2、在感兴趣区为静止或慢流速的 MRI 水成像（如内耳成像、胸髓成像和腰 髓成像）中，SPACE 序列由于高信噪比和对比噪声比优于 CISS 序列；感兴趣区 包含快流速的水成像（如脑脊液成像、颈髓成像）时，CISS 序列因不易产生流 空伪影优于 SPACE 序列。关键词：脑脊液成像、水成像、CISS 序列、SPACE 序列IIMagnetic Resonance Imaging of intracranial cerebrospinal fluid imaging : comparison between 3D CISS and3D SPACE sequencesDepartment of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyCandidate : Mei Hao Supervisor : Prof. Jianming YuABSTRACTObject: To assess the difference between the SPACE sequence and the CISS sequence in hydrography and thus to advise the choice of the two sequences in Cisternography and MR hydrography relate to other body part.Method: 50 patients were examined using 3D CISS and 3D SPACE at 3T MRI, include 45 healthy volunteers and 5 patients with hydrocephalus. First, Paired χ2-test was used to compare the differences of artifact in lateral ventricle and near cerebral aqueduct in order to evaluate the difference of artifact in different flow water imaging between the two sequences. Second, the signal of CSF in lateral ventricle and brain tissue were measured. The CNR and SNR were computed for the CSF and brain tissue on images with the SPACE and CISS sequences. Paired t-test was applied to assess CNR and SNR in order to compare the difference