瞬时受体电位通道高血压治疗的新靶点幻灯片.pptVIP

瞬时受体电位通道 ---高血压治疗的新靶点 Transient Receptor Potential Channels A novel target for treatment of Hypertension 祝之明;;高血压的非药物干预;高血压的药物治疗;高血压的药物治疗 (Drugs related to RAAS);降压效应难于完全用药理机制解释;细胞钙是血管功能调控的重要信号分子钙信号调节异常是高血压血管阻力增高的重要特征;Lifton RP, Cell, 2001 O’Shanghnessy KM, JCI, 2004;Cosens, D. J. Manning, A. Abnormal electroretinogram from a Drosophila mutant. Nature 224, 285-287 (1969); 一种新的非选择性阳离子通道家族，体内分布广泛，分不同的亚型;TRP通道与疾病的联系;TRPC6 in hypertension;Role of TRPV1 in hypertension;Role of TRPM7 in hypertension;高血压病人和SHR单核细胞TRPC3表达上调，其介导的钙内流增加;Role of TRPC3 in the pathogenesis of hypertension;Iden