有机合成讲义ORGANOMETALLIC COMPOUNDS1.pptVIP

Organometallic Compounds I. Concepts and principles Compounds with C-M bond. M = metal A. Preparation 1. From metals and organic halides 2. Metal-halogen exchange 3. Metal-metal exchange 4. Metalation of hydrocarbons B. General reactions of organometallic compounds 1. Sustitution ( nucleophilic ) 2. Addition to double bonds II. Organomagnesium compounds (Grignard reagents) X = Cl, Br, I Order of reactivity: I Br Cl F Soluble in ethers such as diethyl ether and THF. dimer Vinyl halides Acetylenic Grignard reagents Reactions and applications of Grignard reagents A. Formation of carbon-carb