有机合成讲义ORGANOMETALLIC COMPOUNDS2.pptVIP

III. Organolithium compounds A. Preparation More reactive than Grignard reagents towards alkyl halides Wurtz coupling reaction B. Reactions Similar as the Grignard reagents, but more effective. The differences from Grignard reagents Less readily prevented by steric hindrance from reacting at carbonyl groups. 2. 1,2-addition , with a,b-unsaturated ketones 3. Wurtz coupling 4. Carbon dioxide 5. Vinyl double bonds Aromatic heterocycles IV. Organocopper compounds A. Preparation B. Reactions 1. With alkyl halides Lithium organocuprates Organocoper compounds Configuration retained 2. With a