热疗联合培美曲塞、顺铂治疗中晚期肺腺癌的疗效分析.doc

热疗联合培美曲塞、顺铂治疗中晚期肺 腺癌的疗效分析 郑国宝张建国 解放军中心医院肿瘤科 R的:观察热疗联合培美曲塞、顺铂治疗屮晚期肺腺癌的疗效和安全性。方法： 回顾性分析120例中晚期肺腺癌患者资料，按治疗方案不同分为对照组（60例） 和观察组（60例）。对照组患者给予注射用培美曲塞二钠500 mg/m2,静脉滴注, dl+注射用顺铂75 mg/m2,静脉滴注，d24 （分3 d使用）。21 d为1个周期，至 少化疗2个周期。观察组患者在对照组化疗的基础上行热疗每月1次，共21次。 观察两组患者的临床疗效，生活质量改善情况及毒副反应发生情况。结果:两组 患者至少接受2个周期治疗。观察组患者总有效率（63.3%）显著高于对照组 （36.7%）,生活质量改善率（60.0%）显著高于对照组（33.3%）,差异均有统计 学意义（P0.05）。两组患者IIP度肝肾功能损害、骨髓抑制、消化道反应发生 率比较，差异均无统计学意义（P〉0.05）。结论:热疗联合培美曲塞、顺铂治疗 屮晚期肺腺癌的疗效显著，可提高生存质量，且未増加严重毒副反应的发生率。 关键词： 热疗;培美曲塞;顺铂;中晚期肺腺癌;疗效;安全性; 郑国宝，主任医师，。研究方向:肺癌的综合治疗。电 话：0379E-mail:zhengguobaol23@126. com 2017-06-14 Analysis of Therapeutic Efficacy of Hyperthermia Combined with Pemetrexed and Cisplatin in the Treatment of Medium and Advanced Lung Adenocarcinoma ZHENG Guobao ZHANG Jianguo Dept. of Oncology， No. 150 Center Hospital of PLA; Abstract： OBJECTIVE: To observe therapeutic efficacy and safety of hyperthermia combined with pemetrexed and cisplatin for medium and advanced lung adenocarcinoma. METHODS:Medical information of 120 patients with medium and advanced lung adenocarcinoma were analyzed retrospectively. They were divided into control group (60 cases) and observation group (60 cases) according to therapy method. Control group was given Pemetrexed di sodium for injection 500 mg/m2 intravenously, dl+Cisplatin for injection 75 mg/m2 intravenously, d2~4. A treatment course lasted for 21 d, and both received 2 courses of treatment at least. Observation group was additionally given hyperthermia, once a month, 2-4 times in total, on the basis of control group. Clinical efficacies, the improvement of life quality and the occurrence of toxic reaction were observed in 2 groups. RESULTS:Both groups received 2 courses of treatment at least. Total response rate of observation group (63. 3%) was significantly higher than that of control group (36. 7%)，and the improvement rate of life quality (60.0%) was significantly higher than control group (33. 3%)，with statistical significance (P0.05) . There was n