改质PBT不织布膜以离子诱导接枝聚合应用於白血球过滤.PDF

改質PBT 不織布膜以離子誘導接枝聚合應用於白血球過濾 The leukocyte filtration membrane application from PBT nonwoven plasma-induced graft polymerization and modified 1 1 2 于大光* （30％）、劉祐呈 （70％）、陳加霖 1 2 桃園創新技術學院創意流行時尚設計系 .敏成股份有限公司 1 1 2 Da-Guang Yu , You-Cheng Liou , Jia-Lin Chen Department of material and fiber, Fashion and Design Division;Taoyuan Innovation Institute of Technology 1 Mytrex Industries, Inc.2 摘要 本計劃以 PBT (Poly Butylene Terephthalate) 聚對苯二甲酸丁二酯不織布膜改進其親水性及生 物相容性，在其表面經電漿接枝AA (acrylic acid)丙烯酸聚合而產生－COOH 官能基。然後與 (chitosan)幾丁聚醣反應 ，作為延伸鏈。再接上 (heparin) 肝素。測試改質後接枝密度及親水 性。結果顯示接枝改質後親水性增加，而肝素之接枝可延長血液凝固外，也可增加親水性， 而三層複合之改質不織布膜可濾除33% 白血球。若複合四十幾層將可達99.2%之白血球濾除 率。概括而言 ，本研究的最大之成就為固定化肝素於PBT 不織布表面可有效的改善血液相容 性及親水性。 Abstract Aiming to improve the hydrophilicity and hemocompatibility of poly(butylenes terephthalate) (PBT) fibers, PBT fibers were treated with oxygen plasma, followed by graft-polymerization of acrylic acid (AA) to introduce carboxyl groups. Subsequently, chitosan and heparin were covalently bonded onto the AA-grafted PBT fibers. The surface graft density of modified PBT fibers was detected by dyeing and the hydrophilicity was evaluated by the contact angle. The results show that by the coupling of chitosan, the heparin-immobilized amount can be s