[医药卫生]积极降脂_有效防治冠心病----从指南到实践.pptVIP

Summary Point: Inhibition of cholesterol absorption combined with inhibition of cholesterol synthesis with a statin may provide greater LDL-C reductions given the complementary targets of exogenous and endogenous cholesterol with these approaches. Inhibition of endogenous cholesterol synthesis with statins is a common therapeutic approach to lowering LDL-C. Statins competitively inhibit HMG-CoA reductase, an enzyme that catalyzes the conversion of HMG-CoA to mevalonate, a precursor of cholesterol. Given the dose-response limitations of statins1,2, known as the “Rule of Six”, and potential for