金属硫蛋白在动物体内的功能及其基因表达调控.PDFVIP

27 4 2010 7 Vol.27 No.4 Studies of race Elements and Healt h Jul. 2010 金属硫蛋白在动物体内的功能及其基因表达调控 1, 2 3 1, 2 , , ( 1. 中国农业科学院北京畜牧兽医研究所矿物元素营养研究室; 2. 动物营养学国家重点实验 室: 北京100193; 3. 山东 鄄城县郑营乡鲁王仓中学, 鄄城274607) : 金属硫蛋白(metallothioneins, M s) 是一类富含金属和巯基的低分子量蛋白质,在动物体内金属元素的 代谢清除自 基应激防护等方面发挥重要作用M 基因的表达是通过M 基因启动子上的几种反应元 件 许多生化介质引发的综述了M 在动物体内的功能及其基因表达的调控作用及主要机制 : 金属硫蛋白; 功能; 基因表达 : Q513 : A : 1005- 5320( 2010)04- 0058- 04 The function and gene expression regulation of metall othionein in animals 1, 2 3 1, 2 LU Lin , CHEN Z i- xian , LUO Xu- gang ( 1. I nst it ute of A nimal Science, Ch inese A cademy of A gr ic ult ural Scienc; 2. State K ey L aboratory of A nimal N utr ition: Bei ing 100193; 3. Shandong Juancheng z hengying L uw ang cang M iddle School , J uancheng , 274607, Ch ina) Abstract: Metallothioneins (M s) are low molecular weight proteins w hich are rich in metal and thiol content. hey play a great role in the metabolism of metals, removal of free radicals, and stress protection. M gene expression is driven by a number of biochemical mediators through several response elements in the M gene promoter. his article reviews the function and gene expression regulation of M as well as the modes of action of M gene expression in animals. Key Words: Metallothionein; function; gene expression ( metallothioneins, M s) , M , 1957 , , 4 M , M , 2500 , 1957 , M Marg