内科学淋巴瘤大课 ppt课件.pptVIP

* 淋巴瘤国际预后指征（IPI） A 年龄（Age） 60 岁 P 身体状况 （Performance Status） 1分（KPS） L LDH 正常2倍 E 结外病变 1处 S 分期 （Stage） II期 低危组: 积分 0-1 低中危组: 积分 2 中高危组: 积分 3 高危组: 积分 4 * 国际预后指数（IPI）与生存期 Time (Months) 0 80 100 120 140 160 20 40 60 0.0 0.5 0.6 0.7 0.8 0.9 1.0 0.4 0.3 0.2 0.1 Probability of survival IPI 0~1 IPI 2~3 IPI 4~5 Apelgren P et al. Leuk Lymphoma 2006;47:2505-2516 * 展 望 淋巴瘤的诊断技术 生物芯片 个体化诊断 淋巴瘤的综合治疗 生物治疗 个体化治疗 * * * Slide 2: Increasing Incidence of NHL The incidence of non-Hodgkin’s lymphoma (NHL) is on the rise. As the population ages, the incidence of NHL tends to increase. (Ries et al, 2003) This trend was observed from 1975 to 1977 and from 1998 to 2000. However, from 1998 to 2000, the overall incidence of NHL has shown a more dramatic increase in men past the fifth decade of life. Ries LAG, Eisner MP, Kosary CL, et al (eds). SEER Cancer Statistics Review, 1975-2000, National Cancer Institute. Bethesda, MD, /csr/1975_2000, 2003. * Slide 3: Classification of NHL: Searching for the Gold Standard For more than half a decade, clinicians have been in pursuit of a uniform “gold standard” classification system for NHL. (Harris et al, 2000; Armitage and Weisenburger, 1998) Early classification systems were driven by the thought that a single basis of classification was an important prerequisite for clinical acceptance. Sophistication of histopathologic diagnosis of NHL as well as enhancement of immunologic and genetic techniques has led to an increased understanding of NHL (Adult NHL, , 2003) Therefore, a new classification system, the Revised European American Lymphoma (REAL) classification, was created by European and American hematopathology societies. (Adult NHL, , 2003) The World Health Organization (WHO) has adopted and updated the REAL system. This new system is based upon the inclusion of