PDGF-BBPDGFR-β与肿瘤发生发展的研究进展.PDFVIP

临床与病理杂志 2017, 37(11) J Clin Path ol R e s 2457 doi: 10.3978/j.issn.2095-6959.2017.11.028 ·综述 · View this article at: /10.3978/j.issn.2095-6959.2017.11.028 PDGF-BB/PDGFR-β 与肿瘤发生发展的研究进展 汤伟伟 综述 何永文 审校 (昆明医科大学附属口腔医院口腔颌面外科，昆明 650031) [摘　要] 血小板衍生生长因子 ( platelet-der ived grow th factor ，PD GF) 是一类重要的促血管生成因子，是 多种细胞的促有丝分裂剂和趋化因子，血小板衍生生长因子受体 ( platelet-der ived grow th factor receptor ，PDGFR)是络氨酸蛋白激酶家族成员，能促进细胞的趋化增殖，PDGF 和PDGFR 在肿瘤 发生发展中起着重要作用，以PDGF/PDGFR 为靶点作为肿瘤靶向治疗的研究也有了较大的进展。 [关键词] PDGF-BB/PDGFR- β ；肿瘤；靶向治疗 β Research progress of PDGF-BB/PDGFR- in tumor TANG Weiwei, HE Yongwen (Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Kunming Medical College, Kunming 650031, China) Abstract Platelet-derived growth factor (PDGF) is a kind of angiogenic factor, is a variety of cell mitogenic agents and chemokines, platelet-derived growth factor receptor (PDGFR) is a member of the lysine protein kinase, which can promote the chemotaxis of cells. PDGF and PDGFR play an important role in the development of tumor. The study of PDGF/PDGFR as a target for tumor therapy has also made great progress. In this paper, review the progress of PDGF-BB/PDGFR-β in the development of tumor and the progress of tumor targeting therapy. Keywords PDGF-BB/PDGFR- β; tumor; targeted therapy 血小板衍生生长因子 ( platelet-derived grow th 因子与肿瘤的发生发展有着密切联系，是多种肿瘤 factor ，PDGF) 家族在胚胎正常发育、细胞生长分