毕业设计（论文）-基于黄酮的反应型氟离子荧光探针的合成精选.docxVIP

基于黄酮的反应型氟离子荧光探针的合成目录摘要IAbstractII前言1第一章文献综述21.1氟离子检测的方式21.1.1离子色谱法21.1.2氟离子选择电极法21.1.3氟试剂比色法21.1.4荧光探针法31.2荧光探针简介31.2.1氟离子荧光探针31.3课题来源和研究内容7第二章基于黄酮的反应型氟离子荧光化学传感器的合成82.1实验试剂与设备82.1.1 实验试剂82.1.2实验所用设备82.1.3实验准备92.2 实验部分92.2.1化合物合成路线92.2.2目标化合物的合成方法10第三章结果讨论与分析15结论19文献21基于黄酮的反应型氟离子荧光探针的合成摘要：氟离子广泛存在于自然水、土壤、和动植物中且为体积最小的阴离子，并与于神经毒气、生活中饮用水、核武器中铀元素的提炼、龋齿防治的临床诊断密切相关。因此关于氟离子检测方法越来越受到人们的重视。发展可专一识别氟离子的探针在各个领域具有非常重要的意义。本论文在翻阅大量文献的基础上合成了一种基于硅氧键断裂机制的氟离子荧光探针。以三羟基黄酮为荧光基团，叔丁基二苯基硅基为羟基保护基团设计合成了特殊的含羟基的三羟基黄酮衍生物，氟离子引起硅氧键断裂诱发一系列分子串联反应。通过液相质谱、核磁共振、荧光光谱等对化合物进行结构和性能的检测。最后通过详细的光谱实验验证了其对于氟离子特异性检测的机理。关键词：氟离子荧光探针 3-羟基黄酮衍生物荧光化学传感器Synthesis of a reactive fluorescent probe for fluorine ion based on flavoneAbstract：Fluorine ion exists widely in natural water, soil, and plants and animals and the minimum volume of anions and nerve gas, in life and in drinking water, nuclear weapons in uranium refining, the prevention of dental caries is closely related to the clinical diagnosis. Therefore, more and more attention has been paid to the detection of fluoride ions. It is very important to develop a probe which can be used to identify fluoride ions in various fields.On the basis of a large number of literatures, this paper synthesized a kind of fluoride ion fluorescent probe. A special hydroxyl containing three hydroxy flavone derivatives were designed and synthesized by using hydroxyl group of as hydroxyl group and hydroxyl group of TBDPS. The structure and properties of the compounds were determined by liquid chromatography mass spectrometry, nuclear magnetic resonance spectroscopy and fluorescence spectroscopy. Finally, the mechanism of fluoride ion specific detection was verified by detailed spectroscopic experiments.Key words: Fluoride ion fluorescent probe; 3- hydroxy flavone derivative; fluorescent chemical sensor前言阴离子在化工，生物以及环境方面有着重要的应用价值，近年来关于阴离子的检测和识别引起了人们的极大关注。特别是阴离子引起的颜色变化的化学传感器，其具有灵敏度高、选择性好、成本低廉方便快捷等优点。其中氟离子检测尤为重要，因为氟离子广泛存在于自然界中，在阴离子中体积为最小。在有机物中引入氟离子会使其很多性质发生改变，氟元素在人体中属于微量元素且自然界中氟元素的存在形式主要以氟化