新生儿窒息后血清心肌肌钙蛋白I测定及临床意义.pdfVIP

2003 20 2 ! 83 ! I 1 2 黄莉芬 张 晓 1 2 武钢总医院儿科 ( 湖北武汉430080) 武汉大学人民医院儿科 : 探讨新生儿窒息患儿血清心肌肌钙 白 I( cTn- I) 水平及临床意义: 采用全自动化学免疫系统检测40 例新生儿窒息 患儿( 轻度窒息重度窒息) 血清 cTn- I 和肌酸磷酸激酶心型同功酶( CK- MB) , 并与 10 例健康新生儿进行对照比较: 各组窒息新生儿血 清 cTn- I 浓度明显升高, 轻度窒息组重度窒息组两两之间及与对照组相比均差异显著( P 005) 窒息组血清中cTn- I 浓度与CK- M B 浓 度呈显著正相关( r = 0669, P 005) 窒息组中有心血管并发症与无心血管并发症患儿血清 cT n- I 浓度比较有显著差异( P 005) , 且重度 窒息组中两者差异更显著( P 001) 轻度窒息组和重度窒息组中有心血管并发症组患儿血清cT n- I 浓度比较差异显著(P 005) ; 而无心血 管并发症组患儿血清 cTn- I 浓度相比无显著差异( P 005) : cT n- I 可作为新生儿窒息所致急性心肌损伤的辅助诊断指标 新生儿窒息 心肌肌钙 白( cTn- I) 心肌损伤 R 72212 A 1005- 5495( 2003) 02- 0083- 03 1 2 The clinical significance of serum cardiac troponin I detection after asphyxia neonatorum.H uang Lif en , Zhang X iao . Department of Pediatrics, The 1 2 General Hosp ital of Wuhan I ron and Steel omp any , Wuhan 430080. Department of Pediatrics, The Peop le Hosp ital of Wuhan University . Abstract Objective:To in estigate the clinical significance of serum cardiac troponin I( cTn- I) le el after asphyxia neonatorum. Methods:T he serum cTn- I and the CK- MB of 40 patients w ith asphyxia neonatorum( mild asphyx iase ere asphyxia) were detected by full- automatic chemo- immune system, and w ere compared w ith 10 cases of health new - born. Results:T he concentration of serum cT n - I in arious asphyx ia neonatorum groups increased ob iously, the mild asphyxia group compared w ith the se ere asphyx ia group, and these tw o groups com pared w ith the control group, there