Ligation of bronchial artery in sheep attenuates early…早期支气管动脉结扎会减弱.pdfVIP

J. Appl. Physiol. 88: 888–893, 2000. Ligation of the bronchial artery in sheep attenuates early pulmonary changes following exposure to smoke OLGA EFIMOVA, A. B. VOLOKHOV, SAKINEH ILIAIFAR, AND C. A. HALES Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114 Efimova, Olga, A. B. Volokhov, Sakineh Iliaifar, and shown that the airways are swollen and edematous, but C. A. Hales. Ligation of the bronchial artery in sheep there is also peribronchial cuffing, septal thickening, attenuates early pulmonary changes following exposure to and peribronchial alveolar edema, especially around smoke. J. Appl. Physiol. 88: 888–893, 2000.—Smoke inhala- the respiratory bronchioles (11–13, 15, 16, 18). The tion can produce acute pulmonary edema. Previous studies peribronchial cuffing may be due to the suspected have shown that the bronchial arteries are important in acute pulmonary edema occurring after inhalation of a synthetic negative pressure in this area acting as a sump (25). smoke containing acrolein, a common smoke toxin. We hypoth- However, the peribronchiolar location of the edema esized that inhalation of smoke from burning cotton, known may represent spillover from the edematous airways, to contain acrolein, would produce in sheep acute pulmonary which are supplied by the bronchial arteries. edema that was mediated by the bronchial circulation. We Although the largest blood supply to the lungs comes reasoned that occluding the bronchial arteries would elimi- from the pulmonary arteries, it has been demonstrated nate smoke-induced pulmonary edema, whereas occlusion of that the bronchial arteries, which account for only the pulmonary ar