Long Terminal Repeat Selective CpG Methylation of Latent…长末端重复选择性潜在甲基化.pdfVIP

JOURNAL OF VIROLOGY, Sept. 2002, p. 9389–9397 Vol. 76, No. 18 0022-538X/02/$04.00 0 DOI: 10.1128/JVI.76.18.9389–9397.2002 Copyright © 2002, American Society for Microbiology. All Rights Reserved. 5-Long Terminal Repeat-Selective CpG Methylation of Latent Human T-Cell Leukemia Virus Type 1 Provirus In Vitro and In Vivo Tsukasa Koiwa,1 Akiko Hamano-Usami,1 Takaomi Ishida,1 Akihiko Okayama,2 Kazunari Yamaguchi,3 4 1 Shimeru Kamihira, and Toshiki Watanabe * Division of Pathology, Department of Cancer Research, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639,1 Department of Internal Medicine, Miyazaki Medical College, Miyazaki 889-1601,2 Blood Transfusion Service, Kumamoto University, Kumamoto 860-8556,3 and Department of Laboratory Medicine, Nagasaki University, Nagasaki 852-8523,4 Japan Received 25 March 2002/Accepted 5 June 2002 D o CpG methylation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeat (LTR) has been w implicated in proviral latency, but there is presently little information available regarding the pattern of LTR n l