Total Synthesis and Biological Evaluation of C Analogs of …类似物的全合成和生物评估.pdfVIP

Total Synthesis and Biological Evaluation of C16 Analogs of ()-Dictyostatin Won-Hyuk Jung,† Cristian Harrison,† Youseung Shin,† Jean-Hugues Fournier,† Raghavan Balachandran,‡ Brianne S. Raccor,† Rachel P. Sikorski,§ Andreas Vogt,§ Dennis P. Curran,*,† and Billy W. Day*,†,‡ Department of Chemistry, Department of Pharmaceutical Sciences, and Department of Pharmacology, Uni ersity of Pittsburgh, Pittsburgh, Pennsyl ania 15261 Recei ed December 1, 2006 The structureactivity relationship of the crucial C16 region of ()-dictyostatin was established through total