Trk Receptor Expression and Inhibition in Neuroblastomas受体在神经母细胞瘤中的表达和抑制.pdfVIP

Molecular Pathways Trk Receptor Expression and Inhibition in Neuroblastomas Garrett M. Brodeur,1,2 Jane E. Minturn,1,2 Ruth Ho,1 Anisha M. Simpson,1 Radhika Iyer,1 Carly R. Varela,1,2 Jennifer E. Light,1 Venkatadri Kolla,1 and Audrey E. Evans1 Abstract Neuroblastoma, the most common and deadly solid tumor in children, exhibits hetero- geneous clinical behavior, from spontaneous regression to relentless progression. Current evidence suggests that the TRK family of neurotrophin receptors plays a critical