缺血性脑卒中抗血小板药物治疗精选.ppt

* Current antiplatelet agents include: Thromboxane A2 inhibitor Acetylsalicylic acid (ASA) Phosphodiesterase inhibitor Dipyridamole Glycoprotein (GP)IIb/IIIa blockers Parenteral: abciximab, eptifibatide, tirofiban Oral GPIIb/IIIa blockers (lotrafiban, orbofiban, sibrafiban, xemilofiban) have been examined in major clinical trials, but failed to demonstrate efficacy vs ASA. ADP-receptor antagonists Clopidogrel Ticlopidine TIA/MIS的处理原则（二级预防的最佳时机） 1.紧急处理：查找病因和开始治疗 2. 针对病因的处理 3.个体化，具体化，现实化（理论转化为实际；群体转化为个体；理想转化为现状；国外转化为国人） 4. 几个比率的平衡：疗效/不良反应；利益/cost; 商业行为/病人利益；行政法规/医护人员负担/病人实际利益 5.疗效的不可见性：确保患者的知