抗生素课件课件(英文精品) Antibiotics(51p).pptVIP

Chapter 8 Antibiotics;Antibiotics as disturber with the biosynthesis of protein ;Tetracycline Antibiotics ;Tetracyclines are produced by actinomyces (放线菌), which have broad-antibacterial spectrum. The basic skeleton of tetracyclines is naphthacene ring. Tetracyclines differing from each other chemically only by substituent variation at positions 5,6 and 7.;Tetracycline pharmacophore and numbering ;Mechanism of Action: Tetracyclines inhibit bacterial protein synthesis by blocking the attachment of the t-RNA-amino acid to the ribosome. Tetracyclines can also inhibit protein synthe