(精选)【高血压英文课件精品课件】Gender Differences in Physiology Cardiovascular教学课件.pptVIP

Gender Differences in Physiology: Cardiovascular Virginia H. Huxley, Ph.D. Director, National Center for Gender Physiology University of Missouri School of Medicine Columbia, MO USA;Surprize!M≠F;Definitions: Sex vs. Gender;Physiology: Cardiovascular;QT interval longer in Women than Men Atrial Fibrillation in Men who are heavy drinkers Contractility Women Men Cardiac myocyte expression of glycolytic mitochondrial enzymes differs;Pathophysiology: Cardiovascular;Cardiac arrest ~ 3x in Men than Women, but lower recovery and survival rates in Women;Pathophysiology: Type II Diabetes CVD;Basic truths;Estrogen: The (?) Mediator of Sex Differences;Estrogen: The (?) Mediator of Sex Differences;Remember the others…. ;Progesterone;Testosterone;Solution;water;Volume flow is determined by the balance of hydrostatic and osmotic pressures across a semipermeable membrane.;Geigy Scientific Tables Vol. 3, 1984 p. 140-141;“Oncotic Pressure, ?” Onsager’s Law: π = FnC;Right Heart (Right Atrium);Males = Females?;Pcap: FemalesMales;Assume: Lp and S are the same in M F in health and disease;Males = Females?;With respect to response, NO!;Venules;How can “sex” influence one parameter, permeability response to a stimulus, and not another, basal permeability?;-20;London, UK;Just as the direction of travel between London and Christchurch can matter, so too can males and females of the same species be in balance with respect to volume and solute exchange, but not by the same means. ;Why should Teachers of Physiology care?;Signs of Heart Attack:;But, ;Future Challenge ~ Reality; Differences between Men and Women noted in normal organ functions in health as well as in disease, including diabetes and cancer.