白藜芦醇的放射防护作用及其机制研究进展.pdfVIP

·综述· 白藜芦醇的放射防护作用及其机制研究进展 高飘阳 杜利清 刘强 300192 天津，中国医学科学院 北京协和医学院放射医学研究所 天津市放射医学与分子核 医学重点实验室 通信作者：刘强，Email: liuqiang@irm-cams.ac.cn DOI: 10.3760/cma.j.issn.0254-5098.2018.04.0 【摘要】白藜芦醇作为一种天然活性物质，具有较强的抗氧化性和放射防护作用。体内 外研究表明，白藜芦醇能够减轻放射损伤，在放射防护方面发挥着重要作用，具有良好的应 用前景。本文就白藜芦醇对造血系统、免疫系统、神经系统、呼吸系统以及其他器官的放射 防护作用和其作用机制进行综述。主要包括HO1 信号通路、Nrf2 途径等抗氧化机制以及激 活Sirt1 调节下游信号、促使TyrRs 入核等发挥放射防护的作用，并对白藜芦醇的应用前景 进行了展望。 【关键词】白藜芦醇； 电离辐射； 防护； 机制 基金项目：国家自然科学基金）；中央高校基本科研业务费专项资金(3332016100) Research progresses of the radioprotective effects and mechanism of resveratrol Gao Piaoyang, Du Liqing, Liu Qiang Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences Peking Union Medical College, Tianjin 300192, China Corresponding author: Liu Qiang, Email: liuqiang@irm-cams.ac.cn 【Abstract 】Resveratrol is a kind of natural active substance, which has strong antioxidant activity and radioprotective effect. A large number of studies have shown that resveratrol can attenuates radiation damage and play an important role in radiation protection and hence has potential application prospect. This paper reviewed the radioprotective effects of resveratrol on hematopoietic system, immune system, nervous system, respiratory system and so on, and analyzed the underlying mechanisms including the HO1 signaling pathway, Nrf2 pathway and other antioxidant functions, and the activation of Sirt1 that regulates the downstream signals and promotes TyrRs into the nucleus which plays a role of radioprotection. The prospect of application of resveratrol was also discussed. 【Key words 】 Resveratrol; Ionizing radi