(精选)试管婴儿与生殖工程教学课件.pptVIP

试管婴儿与生殖工程 上海医学院 细胞与遗传医学系 左 伋 INFERTILITY Infertility is defined as no ongoing pregnancy after 9-12 months of sexual activity without contraception. There is no distinction between not using contraception and trying to conceive. STATISTICS In 1995, 15% of women of childbearing age had ever sought infertility advice, that includes medical advice, tests, drugs surgery or assisted reproductive technologies (ART). Infertility among Married Women, by Education Level 8.5% of women without high school or equivalent 8.1% of women with just high school or the equivalent 6.6% of those who have some college, but no bachelors 5.6% of women with bachelors or higher Infertile Couples 7.1% or about 2.1 million of married couples were infertile in 1995. 2.3 million were infertile in 1988, and 2.4 in 1982. 6.1 million or 10% of married couples in 1995 had impaired fecundity (either infertile or had problems conceiving or carrying a child to term.) Infertility by Race 7% of Hispanic women are infertile 6.4% of white women are infertile 10.5% of black women are infertile 13.6% of other groups are infertile The causes of infertility Male Factor: Sperm production and sperm quality. Ovulation: Egg production, egg quality and preparation of the uterine lining for implantation. Passage: The joining of sperm and egg in the Fallopian tubes and transport of the fertilized egg into the uterus. In 1995, there were 59,142 cycles of ART. 11,315 women had a live birth delivery through ART. Type of ART procedures 90% in vitro fertilization (IVF) 8% gamete intrafallopian transfer (GIFT) 2% zygote intrafallopian transfer (ZIFT) 11% of ART procedures involved intracytoplasmic sperm injection to fertilize eggs (ICSI). One cycle of IVF costs an average of $7,800. (Includes everything from consultation to transfer) 1995 ART Success Rates CYCLES using fresh embryos from non-donor eggs:Live births per stimulation: 19.6%Live births per retrieval: 22.8%Live births per transfer: 25.1%Mult