(精编)【高血压英文教学精品课件】 Uncontrolled Hypertension, Systolic and Diastolic Blood Pressure and Development of Symptomatic Peripheral Arterial Disease in the Women’s Health Study.pptVIP

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2018-03-21 发布于天津
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(精编)【高血压英文教学精品课件】 Uncontrolled Hypertension, Systolic and Diastolic Blood Pressure and Development of Symptomatic Peripheral Arterial Disease in the Women’s Health Study.ppt

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- Change * * Uncontrolled Hypertension, Systolic and Diastolic Blood Pressure and Development of Symptomatic Peripheral Arterial Disease in the Women’s Health Study (WHS) Tiffany M. Powell, Robert J. Glynn, Mark A. Creager, Paul M. Ridker, Aruna D. Pradhan Harvard Medical School Brigham and Women’s Hospital The authors have no conflicts of interest related to this research. Peripheral Arterial Disease Increasing but under-diagnosed cardiovascular health issue Affects up to 29% of Americans Hypertension linked to PAD development Lacking data on PAD risk prediction related to: Systolic blood pressure (SBP) Diastolic blood pressure (DBP) Criqui,M.H. et al. Vasc Med 2001, Murabito,J.M. et al. Am Heart J 2002 Uncontrolled Hypertension Up to two-thirds of Americans with hypertension are: Untreated Undertreated Control of hypertension to current guidelines reduces coronary artery disease by 57% How does blood pressure and control status relate to PAD risk? Wang,T.J. et al., Circulation 2005 Systolic Blood Pressure and Diastolic Blood Pressure Peripheral Arterial Disease Coronary Artery Disease Cerebrovascular Disease Control Status ? ? PAD Events in WHS Sept 2005 – 482 self-reported cases of symptomatic PAD Symptomatic PAD defined as: Intermittent claudication based on Edinburgh Claudication Questionnaire Documented peripheral arterial surgery inclusive of peripheral angioplasty or stenting 116 confirmed cases of PAD Statistical Analysis Continuous BP values assigned using mid-point of reported BP category. Cox Proportional Hazards Regression Hazard Ratios for incident PAD: According to treatment and BP control status SBP, DBP, Mean Arterial Pressure (MAP), Pulse Pressure (PP) per 10 mmHg and BP categories Global model fit assessed by model log-likelihood statistics. Models of PAD Risk Multivariate models adjusted for: Age (logage) Smoking (never/past/current) Diabetes (no/yes) BMI (continuous) History of Elevated Cholesterol (no/yes cho