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A meta-analysis by Staessen et al shows that differences in SBP account for the CV-event rate reductions observed in the major BP trials. Many of the trials in this meta-analysis were also in the BPLTTC study. These trials included large numbers of women. Staessen et al predicted odds ratios from meta-regression models involving 30 BP trials and 149,407 patients. Odds ratios were calculated for experimental versus reference treatment. Blood pressure differences were obtained by subtracting achieved levels in experimental groups from those in reference groups. Negative values indicate tighte