(精编)Antifungal Agents - 教学教学课件.pptVIP

Systemic Topical Some are fungistatic, while others are fungicidal Fungal Infection in Humans = Mycosis Major Types of Mycoses superficial cutaneous subcutaneous systemic opportunistic Symptoms vary from cosmetic to life threatening Antifungal Agents Polyene antibiotic The polyene antibiotics bind with sterols in the fungal cell membrane, principally ergosterol. This causes the cells contents to leak out and the cell dies. Animal cells contain cholesterol instead of ergosterol and so they are much less susceptible. Nystatin Amphotericin B (may be administered liposomally) Natamycin R