(精编)Novel regulators of gene expression and genome integrity教学课件.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * tRNA-DERIVED SMALL RNAs - A new family of regulatory small RNAs? - Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs COLE C., et al. RNA (2009) Deep sequencing revealed that 5’ halves from tRNAs was the most abundant small RNA population The tRNAs are almost exclusively processed from the 5’ end with cleavage by Dicer at the D-loop resulting in the generation of ~19 nt-long fragments Increased levels of tRNAs might force Dicer to accept tRNAs as substrate (modul