(精编)Sepsis and Cardiac Output Measurement教学课件.pptVIP

Sepsis and Cardiac Output Measurement S Gower Consultant Anaesthetist Aim Glimpse of history of sepsis management Overview of pathophysiology Comment on cardiac output measurement Update on sepsis treatment, particularly early management. History Swan Ganz catheter, 1970 Bp=COxSVR Shoemaker, 1979 DO2 =(SaO2xHb)xCO Supranormal values PA Catheter Recognise decreased CO before it’s too late Pathophysiology of sepsis Margination of leukocytes Induction of nitric oxide synthetase Impaired anticoagulation Microvascular thrombosis DIC Activated Protein C