(精编)Severe Aplastic Anemia教学课件.pptVIP

DBA Outcomes Remission of anemia ~ 20% by age 25 No predictive genetic or clinical features HSCT for transfusion dependent patients, particularly those who are allo-immunized or have OTHER cytopenias (neutropenia) Does not cure solid tumor risk Sibling donor needs careful evaluation for DBA Diamond Blackfan Anemia Malignancy 30 Cases* Reported in the Literature (~5%) AML/MDS 15 ALL 1 Osteosarcoma 6 Hodgkin disease/NHL 3 Breast carcinoma 2 Hepatocellular carcinoma 2 GI carcinoma 2 Melanoma 1 Malignant fibrous histiocytoma 1 Soft tissue sarcoma 1 Non-Hodgkin Lymphoma 1 Fr