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辛伐他汀对慢性心力衰竭兔心室重构、心功能影响及其作用机制.pdf
辛伐他汀对慢性心力衰竭兔心室重构、心功能的影响及其作用机制 英文摘要
withCHF rabbitsreceivedandlatetreatmentof
rabbits，in
Results：Compared early
heart ventricular radiowere
simvastatin，the
weight，left weight，heartweight／bodyweight
were
significantlyless(p0．05-0．01，respectively)，TheIVSd，LVIDssignificantly
EFandFSwere
decreased①0．05—0．01，respectively)，thesignificantlyhigher(pO．05-
less LVEDP
apoptoticindex(AP)Wassignificantly00．01)，The
0．01，respectively)，The
were sizedecreased．Intreatment
significantlylower(p0．05)，cardiomyocyteearly group，
leftventricular andLVPWdwere lessthan
radio，LVIDd
weight／bodyweight significantly
CHFrabbitsalso
00．05-0．01，respectively)．
Inrabbits ofRhoAin
treated
bysimvastatin，the
expression cardiomyocytes
membraneand B1 in were
cyelin cardiomyocytescytosolsignificantlydecreased(p0．01，
diminishedthe ofRho
respectively)．Simvastatinsignificantly activity GTPase(pO．01，
the mRNAand
respectively)．SimvastatinsignificantlypromotedPPAR7 proteinexpression
and ofNF—r,B
(p0．0 were inhibited
1，respectively)．Theexpressionactivity sinificantly
inrabbitstreated
bysimvastatin(p0．01，respectively)．Simvastatinsignificantlypromoted
the of in
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