抗辐射复方中药对辐射损伤小鼠的防护作用研究-中国药事.PDFVIP

132 2011 25 2 黄黎明, 石 鹏, 张琳静, 孙成荣( , 710054) : 对抗辐射复方中药 ( RFT ) 的辐射防护作用进行初步研究 将小鼠分为5 个组, 分别 60 为正常对照组模 组3 个给药剂量组, 连续给药21d, 末次给药后3 采用 Co 射线一次性全身照射 ( 75Gy) , 于照射后记录各给药组存活时间30d 存活率; 另, 分组及给药剂量同前, 连续给药 14d, 60 Co 射线一次性全身照射 ( 3Gy) , 检测各给药组动物外周血白细胞数骨髓细胞DNA 含量胸腺脾 脏指数等 RFT 可提高受照射小鼠的存活率外周血白细胞数胸腺指数脾脏指数和骨髓细胞 DNA 含量由中药黄芪灵芝枸杞和茯苓制成的抗辐射复方中药抗辐射作用确切, 值得进 一步研 究和开发 : 辐射防护; 中药; 小鼠 : R2855 : A : ( 2011) 60 Effects of Radioprotection Formula of TCM on Acute Injury Induced by Co rays in Mice Huang Liming, S i Peng, Z ang Linjing and Sun C engrong ( T e 451t Hospital of PLA, Xi an 710054) ABSTRACT: bjective To study t e effects of radioprotection formula of T CM ( RFT ) Methods M ice w ere divided into 5 groups including t e ealt y control, model control group and t ree experimental groups t at w ere treated w it medicine respectively once a day for 21 days T e model control group and t ree experimental groups w ere irradiated once w it 75 Gy 60 Co rays, and t e difference in survival rates in 30d w ere observed Anot er group w as treated w it t e same medicine once a day for 14 days T e 60 model control group and experimental groups w ere irradiated once w it 3Gy Co rays, and t e c anges in blood cells, t e difference in marrow cell DNA content and index of spleen and t ymus gland w ere observed Results RFT could effectively raise t e 30day survival rate, WBC, DNA content of marrow cell and index of spleen and t ymus gland in mice irradiated w it 60 Co rays Conclusion RFT consisting of radix astragali, ganoderma, fructus lycii and proria is proved to ave t e definite effects on radioprotection KEYW RDS: radioprotection; traditional C inese medicine (T