人类与老鼠单体型图谱之比较分析-NPUCSIE.PDFVIP

第七屆離島資訊技術與應用研討會論文集 人類與老鼠單體型圖譜之比較分析 1 2 2* Trees-Juen Chuang , Ji-Fu Liao , Yao-Ting Huang 1Genomics Research Center Academia Sinica, Taipei, Taiwan. 2Department of Computer Science and Information Engineering National Chung-Cheng University, Chia-Yi, Taiwan. * Corresponding author 論文摘要 species still differed from each other by various types 由於人類與老鼠的單體型圖譜已經被建構出 of genetic variations (e.g., insertion and deletion) (Altshuler et al., 2005; Redon et al., 2006). Therefore, 來，我們可以找尋保留在此二物種之共同祖先單核 the extension of biomedical findings to human 苷酸多型性，與物種特有之單核苷酸多型性。祖先 subjects is not completely accurate due to the lack of 單核苷酸多型性可能經歷過正向天擇，因而從多型 considering genetic variations in both species. 性固定為單型性。這些經歷正向天擇的單核苷酸多 Recently, considerable efforts have been made to 型性，可能為分辨人類與其他物種差異之重要遺傳 sketch genome-wide maps of genetic variations in 變異。本論文致力於設計並實作一系列計算方法與 several species (Zhang et al., 2005; Frazer et al., 統計測試方法，以尋找保留於人類族群中之祖先單 2004; Frazer et al.,